Having your website confused with a popular site already owned by someone else is a recipe for disaster. Thus, I never choose domains that are simply the plural, hyphenated or misspelled version of an already established domain. I still believe that Flickr desperately needs to buy Flicker.com - I hear kids in their 20's tell parents in their 40's and 50's to see photos on Flickr and always envision that traffic going straight to the wrong domain.
When you first begin your domain name search, it helps to have 5 terms or phrases in mind that best describe the domain you're seeking. Once you have this list, you can start to pair them or add prefixes & suffixes to create good domain ideas. For example, if you're launching a mortgage related domain, you might start with words like "mortage, finance, home equity, interest rate, house payment" then play around until you can find a good match.
If a domain name requires considerable attention to type correctly, due to spelling, length or the use of un-memorable words or sounds, you've lost a good portion of your branding and marketing value. I've even heard usability folks toute the value of having the letters include easy-to-type letters (which I interpret as avoiding "q," "z," "x," "c," and "p").
Barr Design
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Imagine a wide open field. Before you can build houses and create neighborhoods, an infrastructure must be put in place.
Underground utilities, shopping, schools and roads are installed much like a framework for your website.